Regenerative Medicine

Advanced Biologic Therapies in The Villages, FL

PRP, stem cell therapy, and the CartiHeal Agili-C™ implant — harnessing your body’s own biology to repair damaged joints, restore function, and renew your quality of life.

Regenerative Medicine — The Villages, FL

Heal With Your
Own Biology.

Regenerative medicine is transforming orthopedic care. Rather than simply masking pain or removing damaged tissue, regenerative therapies work with your body’s natural biology to repair, rebuild, and restore — at a cellular level.

At Advanced Orthopedics Institute, Dr. Alfred J. Cook Jr. offers a full spectrum of regenerative treatments, including platelet-rich plasma (PRP), bone marrow stem cell therapy (BMAC), and the CartiHeal Agili-C™ cartilage restoration implant from Smith & Nephew. These biologic options address conditions of the knee, hip, shoulder, ankle, and soft tissue.

Dr. Cook evaluates each patient individually — reviewing imaging, joint condition, and activity goals — to determine which regenerative approach offers the best chance of meaningful, lasting improvement.

Treatment Options

Regenerative Medicine Approaches

Platelet-Rich Plasma (PRP)

A concentration of your own growth factors injected to stimulate healing and reduce inflammation — a biologic option with growing evidence for knee arthritis pain relief.

Stem Cell Therapy

Stem cell therapy uses your body’s own regenerative cells to help repair damaged joints and soft tissue. At AOI, stem cells are drawn from your own body — eliminating any risk of rejection — then concentrated and precisely delivered to the affected area, where they work to reduce inflammation and support your body’s natural healing process. Dr. Cook will determine whether stem cell therapy is appropriate for your condition during your consultation.

CartiHeal Agili-C™

A bi-phasic resorbable aragonite scaffold from Smith & Nephew — implanted into isolated cartilage defects of the knee to support simultaneous regeneration of articular cartilage and subchondral bone. No donor tissue required. FDA Breakthrough Device designation.

A Personalized Treatment Plan

How We Plan Your Regenerative Care

Step 1 — Comprehensive Evaluation

Dr. Cook reviews your imaging, performs a clinical exam, and discusses your symptoms and goals — determining which regenerative approach is most appropriate for your joint condition.

Step 2 — Treatment Selection

Dr. Cook recommends the right therapy — PRP, stem cell therapy, or the CartiHeal Agili-C™ — matched to your diagnosis, extent of damage, and recovery expectations.

Step 3 — Treatment & Recovery

Your procedure is performed in a state-of-the-art clinical setting. Post-treatment, Dr. Cook’s team provides structured recovery guidance, activity protocols, and follow-up milestones.

AOI’s Regenerative Medicine Program

Biology,
Not Just Bandages.

For many patients — particularly those with early-to-moderate joint degeneration, cartilage damage, or soft tissue injuries — regenerative therapies provide meaningful relief without the risks, recovery time, or permanence of surgery.

Regenerative medicine is especially well-suited for active patients who have meaningful joint function remaining and realistic recovery goals. Whether you’re dealing with a sports injury, early arthritis, or an isolated cartilage defect — Dr. Cook will give you an honest, evidence-based assessment of what therapy can achieve for your situation.

When surgery ultimately becomes the best answer, AOI’s comprehensive orthopedic capabilities provide a seamless next step in the continuum of care.

Frequently Asked Questions

Have more questions? Our team is here to help you understand your options and make the right decision for your health.

Regenerative medicine uses biologic therapies — including platelet-rich plasma, stem cells, and advanced scaffold implants — to promote your body’s natural ability to repair damaged joints, cartilage, and soft tissue. Rather than simply suppressing pain, these approaches aim to restore structure and function at a cellular level.

Cortisone injections reduce inflammation temporarily but do not repair underlying tissue damage and may contribute to cartilage breakdown with repeated use. Regenerative therapies like PRP and BMAC use your body’s own biology to actively promote healing — addressing the underlying cause of pain, not just the symptoms.

Stem cell therapy uses your body’s own regenerative cells to help repair damaged joints and soft tissue. At AOI, stem cells are drawn from your own body — eliminating any risk of rejection — then concentrated and precisely delivered to the affected area, where they work to reduce inflammation and support your body’s natural healing process. Dr. Cook will determine whether stem cell therapy is appropriate for your condition during your consultation.

The Agili-C™ is a bi-phasic resorbable scaffold from Smith & Nephew designed to treat isolated cartilage and osteochondral defects in the knee. Made from naturally derived aragonite, it supports simultaneous regeneration of articular cartilage and the underlying bone. The implant gradually resorbs as new tissue grows in its place — with no donor tissue required. It has received FDA Breakthrough Device designation.

Candidates vary by treatment. PRP and stem cells are generally suited for patients with early-to-moderate arthritis, tendon injuries, or cartilage damage who haven’t fully responded to conservative care. The CartiHeal Agili-C™ is best for active patients with isolated, full-thickness cartilage defects in the knee who are not yet candidates for total joint replacement. Dr. Cook will give you an honest assessment during your consultation.

Most regenerative procedures — including PRP and stem cells — are currently not covered by Medicare or most private insurance plans, as they are classified as investigational by many carriers. Coverage for the CartiHeal Agili-C™ may vary. Our team will provide transparent pricing and discuss all available options during your consultation.